SIX6

SIX homeobox 6

Ensembl:
ENSG00000184302
UniProt:
O95475
OMIM:
606326
Synonyms:
OPTX2, SIX9

Cilia effects upon perturbation of SIX6

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
Microphthalmia - cataract

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

Six3 and Six6 are jointly required to maintain multipotent reti l progenitors and Six3 and Six6 together suppress Wnt/β-catenin sig ling ( 30485816).