SKA1

spindle and kinetochore associated complex subunit 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000262634
UniProt:
Q96BD8
OMIM:
616673
Synonyms:
C18ORF24, MGC10200

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.31) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
abnormal tooth color, preweaning lethality, complete penetrance, abnormal spleen morphology, abnormal bone structure, abnormal skin morphology

Subcellular localization

cilia, cytosol, microtubules, basal body

References: PMID:41005307, PMID:26585297

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Reproduction & sperm

Function

SKA might function during cilium shortening to track the axonemal tip(26585297).