SKP1

S-phase kinase associated protein 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000113558
UniProt:: P63208
OMIM:: 601434
Synonyms:: EMC19, MGC34403, OCP-II, OCP2, P19A, SKP1A, TCEB1L

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.79) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Subcellular localization

cilia, cytosol, nucleoplasm, nucleus, basal body

References: PMID:41005307, PMID:34161574

Functional category

Ciliary assembly/disassembly
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

SKP1 has localized in primary cilia.; The collection of regulators has diverse distributions throughout the cell with Bfar, Cop1, Cul9, Fancg, Skp1a, Uba3, Ube2l3, and Wwp1 showing weak localization to cilia. In addition, Sytl4 localized to the ciliary pocket at the base of the cilium, and Fbxw11 localized to centriolar satellites LoF causes Smo accumulation in cilia at basal state (PMID: 34161574).

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