SLAIN2

SLAIN motif family member 2

Ensembl:
ENSG00000109171
UniProt:
Q9P270
OMIM:
610492
Synonyms:
FLJ21611, KIAA1458

Cilia effects upon perturbation of SLAIN2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=3.12) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
hyperactivity, decreased circulating cholesterol level, decreased circulating bilirubin level, abnormal coat/ hair morphology, decreased circulating triglyceride level, preweaning lethality, complete penetrance

Subcellular localization

basal body, centrosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

SLAIN2 localized to centrosome(21399614).