SLC22A14

solute carrier family 22 member 14

Ensembl:
ENSG00000144671
UniProt:
Q9Y267
OMIM:
604048
Synonyms:
OCTL2, ORCTL4

Cilia effects upon perturbation of SLC22A14

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.87) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

Functional category

  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion

Function

SLC22A14 has localized in flagella.

Model organism evidence

Mus musculus (1 reference)

Although the overall differentiation of sperm was normal, Slc22a14-/- cauda epididymal spermatozoa showed reduced motility with abnormal flagellar bending.

PMIDs: 27811987