SLC24A4

solute carrier family 24 member 4

Ensembl:
ENSG00000140090
UniProt:
Q8NFF2
OMIM:
609840
Synonyms:
NCKX4

Cilia effects upon perturbation of SLC24A4

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.77) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased red blood cell distribution width, preweaning lethality, incomplete penetrance, decreased prepulse inhibition, increased circulating alkaline phosphatase level, increased circulating cholesterol level, increased circulating fructosamine level, enlarged thymus, increased circulating hdl cholesterol level

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ANXA1, ANXA2, ANXA5, S100A5, PMCA1, and NCKX4 (also known as SLC24A4)in the cilia of mouse OSNs (24748648).