SLC26A3

solute carrier family 26 member 3

Ensembl:
ENSG00000091138
UniProt:
P40879
OMIM:
126650
Synonyms:
CLD, DRA

Cilia effects upon perturbation of SLC26A3

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

Functional category

  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Protein processing & maturation

Function

Cl- is required for the entry of HCO3- that is necessary for sperm capacitation, implicating the involvement of SLC26A3 in transporting HCO3-, with CFTR providing the recycling pathway for Cl- (18784352).