SLC38A4

solute carrier family 38 member 4

Ensembl:
ENSG00000139209
UniProt:
Q969I6
Synonyms:
ATA3, NAT3, PAAT, SNAT4

Cilia effects upon perturbation of SLC38A4

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-9.52) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=436, lfc=-0.92) PMID:30270045

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation

Function

SLC38A4 exhibited an opposite regulatory trend in ARL3T31A and ARL3T31A/C118F groups, while IQUB, UNC13D, RAB3IP, and GRIP1 were specifically downregulated in the ARL3T31A/C118F group ( 38457249).