SLC4A7

solute carrier family 4 member 7 (Na+/HCO3- cotransporter NBCn1)

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000033867
UniProt:: Q9Y6M7
OMIM:: 603353
Synonyms:: NBCn1, NBC2, NBC3, SBC2

Cilia effects upon perturbation of SLC4A7

Loss-of-function effect:: Shorter cilia

Subcellular localization

cilium, ciliary membrane, centrosome, spindle

References: doi:10.1242/jcs.260687, PMID:28087731, doi:10.64898/2026.03.26.714467

Function

Na+/HCO3- cotransporter NBCn1; localizes to the primary cilium and ciliary membrane (human MCF-7; Severin 2023) and to centrosome/spindle. Slc4a7 loss shortens cilia and attenuates Hedgehog/GLI signaling (Chamlali 2026); interacts with DYNLL1 and regulates SUFU localization.

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