SLC9A1

solute carrier family 9 member A1

Ensembl:
ENSG00000090020
UniProt:
P19634
OMIM:
107310
Synonyms:
APNH, NHE-1, NHE1, PPP1R143

Cilia effects upon perturbation of SLC9A1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.16) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal eye morphology
Mouse ciliopathy phenotype:
male infertility, polycystic kidney, small kidney

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

Knockdown of either slc9a1, slc9a2, and slc9a3 resulted in a significant reduction in fluid flow velocity, revealing defective mucociliary function in morphant embryos ( 30300884).