SLC9A3

solute carrier family 9 member A3

Ensembl:
ENSG00000281861, ENSG00000066230
UniProt:
P48764
OMIM:
182307
Synonyms:
NHE-3, NHE3

Cilia effects upon perturbation of SLC9A3

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.76, ciliated=58.8%) PMID:26595381

Phenotypes

Mouse phenotype:
decreased prepulse inhibition

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Knockdown of either slc9a1, slc9a2, and slc9a3 resulted in a significant reduction in fluid flow velocity, revealing defective mucociliary function in morphant embryos ( 30300884).