SLC9B1

solute carrier family 9 member B1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000164037
UniProt:
Q4ZJI4
OMIM:
611527
Synonyms:
NHA1, NHEDC1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.88) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
abnormal spleen morphology, abnormal skin morphology, enlarged lymph nodes, enlarged liver, enlarged spleen, abnormal lymph node morphology

Subcellular localization

flagella

References: PMID:27010853

Functional category

  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

NHA2 is specifically localized in the principal piece of sperm tail, which is similar to NHA1 expression pattern (27010853).