SLC9C1

solute carrier family 9 member C1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000172139
UniProt:: Q4G0N8
OMIM:: 612738
Synonyms:: NHE, SLC9A10

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=755, lfc=0.66) PMID:30270045

Subcellular localization

flagella

References: PMID:14634667

Functional category

Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion
Signaling (Hedgehog, GPCRs, ion channels)

Function

Indirect immunofluorescence microscopy of mouse caudal epididymal spermatozoa demonstrated that the NHE was localized to the principle piece of the sperm flagellum (14634667).

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