SLMAP3

sarcolemma associated protein 3

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000197217
OMIM:: 602990
Synonyms:: SLMAP, TAILS

Cilia effects upon perturbation of SLMAP3

Cilia number / % ciliated:: Decrease
Loss-of-function effect:: Decrease

Phenotypes

Mouse phenotype:: Embryonic/perinatal lethality, polycystic kidneys, stunted growth, abnormal organs. Reduced ciliated cells and cilia length in MEFs and chondrocytes.

Subcellular localization

centrosome

References: PMID:39417621

Functional category

Ciliary assembly/disassembly

Function

SLMAP3 KO mice show polycystic kidneys, reduced ciliated cells, and reduced cilia length in MEFs and chondrocytes. SLMAP3 is essential for organogenesis via primary cilia formation. STRIPAK complex member; centrosome constituent. Loss causes embryonic/perinatal lethality with polycystic kidney and PCP signaling defects (PMID:39417621).

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