SMAD3
SMAD family member 3
- Ensembl:
- ENSG00000166949
- UniProt:
- P84022
- OMIM:
- 603109
- Synonyms:
- HST17436, JV15-2, MADH3
Cilia effects upon perturbation of SMAD3
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- decreased exploration in new environment, decreased circulating alkaline phosphatase level, decreased lymphocyte cell number, preweaning lethality, complete penetrance
Subcellular localization
basal body, cilia, cytosol, nucleus, transition zone
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Viral interactions
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Transition zone
- ECM & connective tissue
- Transcription regulation
Function
Downstream of TGFBR1 and 2, which phosphorylate SMAD2/3 at base of cilium upon TGF-尾 stimulation (23746451). Sox2 can interact with Smad3 and inhibit TGF-尾1/Smad3- mediated transcriptio l activity (20011520).
Model organism evidence
Mus musculus (2 references)
Conditional deletion of the ciliopathy gene Cep120, which is essential for centrosome duplication, in the stromal mesenchyme resulted in reduced abundance of interstitial lineages including pericytes, fibroblasts and mesangial cells.
Conditional deletion of Cep120 , a ciliopathy gene essential for centrosome duplication, in the stromal mesenchyme resulted in reduced abundance of pericytes, interstitial fibroblasts and mesangial cells.