SMAD4

SMAD family member 4

Ensembl:
ENSG00000141646
UniProt:
Q13485
OMIM:
600993
Synonyms:
DPC4, MADH4

Cilia effects upon perturbation of SMAD4

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.09) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome, cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Neurogenesis & migration
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Axon guidance & growth
  • ECM & connective tissue
  • Transcription regulation

Function

SMAD4 has localized in ciliary tip,basal body.