SMAD6

SMAD family member 6

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000137834
UniProt:
O43541
OMIM:
602931
Synonyms:
HST17432, MADH6, MADH7

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.98) PMID:41160700

Subcellular localization

basal body, cilia, cytosol, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

SMAD6 has localized in basal body.