SMAD6
SMAD family member 6
- Ensembl:
- ENSG00000137834
- UniProt:
- O43541
- OMIM:
- 602931
- Synonyms:
- HST17432, MADH6, MADH7
Cilia effects upon perturbation of SMAD6
Ciliogenesis screen results (4 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.98) PMID:41160700
Subcellular localization
basal body, cilia, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Transcription regulation
Function
SMAD6 has localized in basal body.
Model organism evidence
Mus musculus (2 references)
Since Smad6 and Smad7 have been known as the intracellular inhibitory factors of the BMP signaling pathway, the activation of the pathway could cause a deficit in ciliogenesis of ependymal cells.
Motile cilia play crucial roles in the maintenance of homeostasis in vivo.