SMAD7

SMAD family member 7

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000101665
UniProt:
O15105
OMIM:
602932
Synonyms:
MADH7, MADH8

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.46) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.83) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.97, ciliated=60.4%) PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.53) PMID:41160700

Subcellular localization

basal body, cytosol, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology
  • ECM & connective tissue
  • Transcription regulation

Function

SMAD7 localizing to the basal body