SMAD7
SMAD family member 7
- Ensembl:
- ENSG00000101665
- UniProt:
- O15105
- OMIM:
- 602932
- Synonyms:
- MADH7, MADH8
Cilia effects upon perturbation of SMAD7
Ciliogenesis screen results (5 screens)
- Kim2016: No effect
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.46) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.83) PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.97, ciliated=60.4%) PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.53) PMID:41160700
Subcellular localization
basal body, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Muscle contraction & physiology
- ECM & connective tissue
- Transcription regulation
Function
SMAD7 localizing to the basal body
Model organism evidence
Mus musculus (2 references)
Since Smad6 and Smad7 have been known as the intracellular inhibitory factors of the BMP signaling pathway, the activation of the pathway could cause a deficit in ciliogenesis of ependymal cells.
Motile cilia play crucial roles in the maintenance of homeostasis in vivo.