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SMAD family member 9

Synonyms:: MADH6, MADH9, SMAD8, SMAD8/9

Subcellular localization

cilia, Nucleoplasm, Cytosol

Function

In the current study, it was further found that the loss of the osteogenic capacity of rat calvarial osteoblasts (ROBs) was associated with the inhibition of the BMP-2/Smad1/5/8 signalling pathway, of which most of the signalling proteins including BMP-2, BMPRII, Smad1/5/8 and p-Smad1/5/8 were found localized to primary cilia. Accompanying the resorption of primary cilia following the cells being exposed to simulated microgravity, the expression levels of these signalling proteins were reduced significantly(36512344).

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