SMCP

sperm mitochondria associated cysteine rich protein

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000163206
UniProt:: P49901
OMIM:: 601148
Synonyms:: MCSP

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.92) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Male Infertility

References: PMID:35207567

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:34336820

Function

Protein–protein interaction analysis revealed that the 14 overlapped proteins between differential expression proteins and differential phosphorylation proteins potentially played a key role in sperm development and motility of the flagellum, including the proteins ODF1, SMCP, AKAP4, FSIP2, and SUN5(PMID: 34336820).

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