SMG5

SMG5 nonsense mediated mRNA decay factor

Ensembl:
ENSG00000198952
UniProt:
Q9UPR3
OMIM:
610962
Synonyms:
EST1B, KIAA1089, LPTS-RP1, LPTSRP1, RP11-54H19.7

Cilia effects upon perturbation of SMG5

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, embryonic lethality prior to organogenesis, hemorrhage, pretal lethality prior to heart atrial septation, spi bifida

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

SMG5 has localized in cilia.