SMG8

SMG8 nonsense mediated mRNA decay factor

Ensembl:
ENSG00000167447
UniProt:
Q8ND04
OMIM:
613175
Synonyms:
C17ORF71, FLJ10587, FLJ23205

Cilia effects upon perturbation of SMG8

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-16.33) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.50) PMID:41160700

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly

Function

SMG8 has localized in cilia.