SMYD2

SET and MYND domain containing 2

Ensembl:: ENSG00000143499
UniProt:: Q9NRG4
OMIM:: 610663
Synonyms:: HSKM-B, KMT3C, ZMYND14

Cilia effects upon perturbation of SMYD2

Cilia number / % ciliated:: Incrased cilia number
Loss-of-function effect:: Longer cilia
Overexpression effect:: Decreased

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.46) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: increased circulating ldl cholesterol level, decreased circulating alanine transamise level, abnormal behavior, increased circulating hdl cholesterol level, increased circulating cholesterol level

Subcellular localization

basal body, cytosol, nucleus

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Depletion or inhibition of CDK4/6 and SMYD2 resulted in increased cilia assembly by affecting microtubule stability and the expression of IFT20(33127671).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.