SNAP23

synaptosome associated protein 23

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000092531
UniProt:: O00161
OMIM:: 602534
Synonyms:: HST17016, SNAP23A, SNAP23B

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.65) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: embryonic lethality prior to organogenesis, increased startle reflex, preweaning lethality, complete penetrance, abnormal coat/hair pigmentation

Subcellular localization

cilia, nucleus

References: PMID:41005307

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation

Function

SNAP23 has localized in primary cilia.

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