SNAP25

synaptosome associated protein 25

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000132639
UniProt:
P60880
OMIM:
600322
Synonyms:
BA416N4.2, DJ1068F16.2, RIC-4, RIC4, SEC9, SNAP, SNAP-25

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.02) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol

References: PMID:19454479, PMID:9452464

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

Regulate rhodopsin delivery, controls ciliogenesis through the expansion of the ciliary membrane and rod outer segments biogenesis (19454479). Potentially involved in membrane trafficking into the outer segment (9452464).