SNX10

sorting nexin 10

Ensembl:
ENSG00000086300
UniProt:
Q9Y5X0
OMIM:
614780

Cilia effects upon perturbation of SNX10

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.59) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
no spontaneous movement, abnormal eye morphology

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Protein processing & maturation
  • Ciliary membrane

Function

Required for the formation of primary cilia and essential for left-right patterning of visceral organs. Binds to V-ATPase to regulate its centrosomal trafficking and Rab8a vesicle trafficking to the ciliary membrane. Those events are crucial for ciliogenesis (21844891).

Model organism evidence

Danio rerio (1 reference)

A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.

PMIDs: 21844891