SNX17

Cilia effects upon perturbation of SNX17

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, endosome, flagella

Functional category

• Ciliary assembly/disassembly
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development

Function

SNX17 functions in early stages of ciliogenesis. Regulates the homeostasis of centriolar satellite proteins including PCM1, CEP131, and OFD1 during serum starvation induced ciliogenesis. Recruits USP9X to antagonise MIB1-induced degradation of PCM1, maintaining the integrity of centriolar satellites. SNX17 deficiency leads degradation of USP9X and PCM1, and disrupts ciliogenesis upon serum starvation (31671755).