SOD2

superoxide dismutase 2

Ensembl:
ENSG00000291237
UniProt:
P04179
OMIM:
147460
Synonyms:
GC1, GCLNC1, IPOB, LNCRNA-GC1, MNSOD

Cilia effects upon perturbation of SOD2

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.94) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.46) PMID:20393562

Ciliopathy associations

  • Retinal Dystrophy/Degeneration

Subcellular localization

cilia associated gene, mitochondria

Functional category

  • Motile cilium & axoneme

Function

Exposure of the ciliates to oxidative stress through the chemical generation of •O2− in the culture medium caused a significant increase in SOD activity in the exposed trophozoites (PMID: 31527617).