SON

SON DNA and RNA binding protein

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000159140
UniProt:
P18583
OMIM:
182465
Synonyms:
BASS1, C21ORF50, DBP-5, FLJ21099, FLJ33914, KIAA1019, NREBP

Cilia effects upon perturbation of SON

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-15.82) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-3.03, ciliated=14.5%) PMID:26595381

Phenotypes

Mouse phenotype:
increased mean corpuscular hemoglobin

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:34406792, PMID:30460047

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

The impact of mRNA splicing on cilia assembly after mitosis of the cell cycle. Splicing regulators SON and XAB2 play an important role in mitosis exit, and thus affect ciliogenesis in G1/G0 phases. The pivotal role of mRNA splicing regulators in cilia assembly and underscores the importance of mitotic regulation in ciliogenesis(PMID: 30460047).