SORD

sorbitol dehydrogenase

Ensembl:
ENSG00000140263
UniProt:
Q00796
OMIM:
182500

Cilia effects upon perturbation of SORD

Ciliogenesis screen results (6 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Candidate (Z2MCilia=0.92) PMID:37771269
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.93) PMID:20393562

Phenotypes

Mouse phenotype:
abnormal spleen morphology, abnormal eye morphology, abnormal skin morphology, increased blood urea nitrogen level

Subcellular localization

flagella

Functional category

  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

SORD has localized in flagella.

Model organism evidence

Mus musculus (1 reference)

By indirect immunofluorescence, SORD was present along the length of the flagella of caudal epididymal sperm.

PMIDs: 18799757