SORD

sorbitol dehydrogenase

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000140263
UniProt:
Q00796
OMIM:
182500

Ciliogenesis screen results (6 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Candidate (Z2MCilia=0.92) PMID:37771269
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.93) PMID:20393562

Phenotypes

Mouse phenotype:
abnormal spleen morphology, abnormal eye morphology, abnormal skin morphology, increased blood urea nitrogen level

Subcellular localization

flagella

References: PMID:25613900

Functional category

  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

SORD has localized in flagella.