SOX17

SRY-box transcription factor 17

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000164736
UniProt:: Q9H6I2
OMIM:: 610928

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.69) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, nuclear membrane, nucleoplasm

References: PMID:41410385, PMID:16574095

Function

The frequencies of the primary cilia in the Sox17+/− gallbladder epithelia appear to be increased, rather than reduced, compared with those in wild type (PMID: 23293295). Endogenous Sox17 was detected primarily in ciliated cells, but not in Clara or alveolar type II cells (PMID: 16574095).SOX17 has located to motile cilia.

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