SOX17
SRY-box transcription factor 17
- Ensembl:
- ENSG00000164736
- UniProt:
- Q9H6I2
- OMIM:
- 610928
Cilia effects upon perturbation of SOX17
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.69) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia, nuclear membrane, nucleoplasm
Function
The frequencies of the primary cilia in the Sox17+/− gallbladder epithelia appear to be increased, rather than reduced, compared with those in wild type (PMID: 23293295). Endogenous Sox17 was detected primarily in ciliated cells, but not in Clara or alveolar type II cells (PMID: 16574095).SOX17 has located to motile cilia.
Model organism evidence
Using a newly engineered transgenic line (sox17:Cry2-GFP), we optogenetically disrupted the intraflagellar transport protein IFT88 in KV progenitors via blue light-induced clustering of CIB1-RFP-IFT88.
Prompted by our recent discovery that Wnt signaling regulates ciliogenesis in the zebrafish Kupffer's vesicle (KV) via Foxj1a, a ciliogenic transcription factor, we decided to elucidate functions of Foxj1a in Wnt-regulated LR pattern formation.
The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling.
These promoters shared common features including the absence of a TATA box, and putative binding sites for several factors implicated in spermatogenesis (CREB/CREM, SOX17 and SPZ1) as well as ciliogenesis (FOXJ1).