SOX5
SRY-box transcription factor 5
- Ensembl:
- ENSG00000134532
- UniProt:
- P35711
- OMIM:
- 604975
- Synonyms:
- L-SOX5, MGC35153
Cilia effects upon perturbation of SOX5
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- ECM & connective tissue
- Transcription regulation
Function
SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia ( 20668334).
Model organism evidence
Mus musculus (2 references)
BACKGROUND: The mammalian sperm-associated antigen 16 gene (Spag16) uses alternative promoters to produce two major transcript isoforms (Spag16L and Spag16S) and encode proteins that are involved in the cilia/flagella formation and motility.
Both the mouse and human SOX5 genes encode a 48-kDa SOX5 protein (S-SOX5) that is only present in tissues containing cells with motile cilia/flagella.