SOX5

SRY-box transcription factor 5

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000134532
UniProt:
P35711
OMIM:
604975
Synonyms:
L-SOX5, MGC35153

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:20668334

Functional category

  • Ciliary assembly/disassembly
  • ECM & connective tissue
  • Transcription regulation

Function

SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia ( 20668334).