SP1

Sp1 transcription factor

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000185591
UniProt:
P08047
OMIM:
189906

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.16) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Subcellular localization

nucleus

References: PMID:23137637

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

SP1 is a pivotal transcription factor for the regulation of CEP131 expression, consequently leading the control of centrosome functions ( 23137637).