SPA17

sperm autoantigenic protein 17

Ensembl:
ENSG00000064199
UniProt:
Q15506
Synonyms:
CT22, SP17

Cilia effects upon perturbation of SPA17

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
prolonged rr interval, decreased heart rate
Mouse ciliopathy phenotype:
male infertility

Subcellular localization

flagella

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Regulatory role in a PKA- independent AKAP complex in both germi l cells and somatic ciliated epithelia. It may also play a role in cell motility (19604394, 15034007). Binds the RII binding domain of AKAP3 along the length of the flagella (15257753).