SPAG17

sperm associated antigen 17

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000155761
UniProt:
Q6Q759
OMIM:
616554
Synonyms:
CT143, FLJ34497, PF6, RP4-776P7.2

Cilia effects upon perturbation of SPAG17

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.60) PMID:41160700

Phenotypes

Mouse phenotype:
impaired righting response, decreased body length, limb grasping

Ciliopathy associations

  • Male Infertility
  • Primary Ciliary Dyskinesia

References: PMID:32988999

Subcellular localization

cilia, nucleus, transition zone

References: PMID:41410385, PMID:29690537

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Transition zone

Function

Encodes a central pair protein present in motile cilia and flagella with a 9+2 axoneme.