SPATA19

spermatogenesis associated 19

Ensembl:: ENSG00000166118
UniProt:: Q7Z5L4
OMIM:: 609805
Synonyms:: CT132, FLJ25851, SPAS1, SPERGEN1

Cilia effects upon perturbation of SPATA19

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Male Infertility

Subcellular localization

flagella

Functional category

Reproduction & sperm

Function

Immunolocalization showed that SPATA19 specifically resides in the sperm tail, appearing first during late spermatogenesis and remaining with mature sperm stored in the epididymis. SPATA19 plays an important role in sperm motility by regulating the organization and function of the mitochondria (PMID: 26265198).

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