SPHK1

sphingosine kinase 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000176170
UniProt:
Q9NYA1
OMIM:
603730
Synonyms:
SPHK

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.16) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal skin morphology

Subcellular localization

cilia, cytosol, nucleus, transition zone

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology
  • Transcription regulation

Function

SPHK1 localized at cilia