SPICE1

spindle and centriole associated protein 1

Ensembl:
ENSG00000163611
UniProt:
Q8N0Z3
OMIM:
613447
Synonyms:
CCDC52, SPICE

Cilia effects upon perturbation of SPICE1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.86) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.30) PMID:41160700

Phenotypes

Mouse phenotype:
improved glucose tolerance, increased circulating alkaline phosphatase level, increased red blood cell distribution width

Subcellular localization

basal body, centrosome, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Transition zone

Function

SPICE1 has localized in basal body, transition zone.