SPINK2

serine peptidase inhibitor Kazal type 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000128040
UniProt:: P20155
OMIM:: 605753
Synonyms:: HUSI-II

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.30) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: increased basophil cell number; decreased erythrocyte cell number; abnormal epididymis morphology

Ciliopathy associations

Male Infertility

References: PMID:35207567, PMID:28554943

Subcellular localization

acrosome, equatorial segment, flagella

References: PMID:31033055

Functional category

Metabolism; Motile cilium & axoneme

Function

The seminal ClTI‐1/SPINK2 protein have role in male fertility of physiologically normal, but with contrasted fertility, breeder males, and identified the physiological proteases that are actually inhibited by ClTI‐1/SPINK2.SPINK2 was localized in the acrosome and midpiece region of ejaculated spermatozoa(PMID: 31033055).

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