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Phenotypes

Mouse phenotype:

abnormal head shape, abnormal retina vasculature morphology, abnormal kidney morphology, persistence of hyaloid vascular system, abnormal midbrain development, cataract, abnormal vitreous body morphology, enlarged kidney, microphthalmia, abnormal neural tube closure

Subcellular localization

Ciliary associated gene, Vesicles, Microtubules

Functional category

• Cilia–cytoskeleton/adhesion links

Function

α-spectrin (SPTN1 or SPTAN1) knockdown reduced ciliate cell numbers after 48-h siRNA transfection(31299042).