SPZ1

spermatogenic leucine zipper 1

Ensembl:: ENSG00000164299
UniProt:: Q9BXG8
OMIM:: 618068
Synonyms:: FLJ25709, NYD-TSP1, PPP1R148

Cilia effects upon perturbation of SPZ1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased neutrophil cell number, uriry bladder obstruction, enlarged ovary, abnormal ovary morphology, abnormal skin morphology, increased red blood cell distribution width, abnormal heart shape
Mouse ciliopathy phenotype:: abnormal kidney morphology, abnormal heart morphology, small kidney, enlarged kidney, abnormal reti morphology, abnormal vitreous body morphology, increased heart weight, cataract

Subcellular localization

flagella, nucleus

Functional category

Reproduction & sperm

Function

SPZ1 localized to flagella (25613900)

Model organism evidence

Mus musculus (1 reference)

These promoters shared common features including the absence of a TATA box, and putative binding sites for several factors implicated in spermatogenesis (CREB/CREM, SOX17 and SPZ1) as well as ciliogenesis (FOXJ1).

PMIDs: 15829580

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