SPZ1

spermatogenic leucine zipper 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000164299
UniProt:: Q9BXG8
OMIM:: 618068
Synonyms:: FLJ25709, NYD-TSP1, PPP1R148

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased neutrophil cell number, uriry bladder obstruction, enlarged ovary, abnormal ovary morphology, abnormal skin morphology, increased red blood cell distribution width, abnormal heart shape

Subcellular localization

flagella, nucleus

References: PMID:25613900

Functional category

Reproduction & sperm

Function

SPZ1 localized to flagella (25613900)

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