SREBF1
sterol regulatory element binding transcription factor 1 [Source:HGNC Symbol,Acc:HGNC:11289], sterol regulatory element binding transcription factor 1
- Ensembl:
- ENSG00000072310
- UniProt:
- P36956
- Synonyms:
- BHLHD1, SREBP-1C, SREBP1, SREBP1A
Cilia effects upon perturbation of SREBF1
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
- Overexpression effect:
- Not Reported, Reduced cilia numbers
Ciliogenesis screen results (5 screens)
- Kim2016: No effect
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.90) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.68, ciliated=58.2%) PMID:26595381
- Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=5.64) PMID:20393562
Subcellular localization
cilia associated gene, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- T cell biology
- Signaling (Hedgehog, GPCRs, ion channels)
- Muscle contraction & physiology
- Transcription regulation
Function
SREBP1c-induced loss of the primary cilium could be confirmed in mammalian Madin-Darby canine kidney (MDCK) cells and was mediated by changes in the supply of fatty acids(20889723, 25904332)., Also known as SREBP1. Suppresses primary ciliogenesis. Induces large levels of lysophosphatidylcholine and lysophosphatidylethanolamine , which are typically generated at the outer membrane leaflet. It increases the positive membrane curvature in the plasma membrane and vesicle membranes, causing Rab11- positive vesicles to deviate away from the pericentrosomal preciliary compartment at the ciliary base, suppresing ciliogenesis ( 25904332).
Model organism evidence
The number of primary cilia was reduced by shRNA and chemical methods, leading to elevated transcripts of Pparγ, Cebp-α, Srebp-1, and Fasn and protein levels of PPARγ and FASN.
PMIDs: 28671279