SRGAP2

SLIT-ROBO Rho GTPase activating protein 2

Ensembl:
ENSG00000266028
UniProt:
O75044
OMIM:
606524
Synonyms:
ARHGAP34, FNBP2, KIAA0456, SRGAP2A

Cilia effects upon perturbation of SRGAP2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=3.01) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

SRGAP2 has localized in basal body.