SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

Ensembl:
ENSG00000196220
UniProt:
O43295
OMIM:
606525
Synonyms:
ARHGAP14, KIAA0411, MEGAP, SRGAP2, WRP

Cilia effects upon perturbation of SRGAP3

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Shorter cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Regulates the actin cytoskeleton, forming a sig lling complex with WAVE-1 to regulate its activation. 10% of SrGAP3 knockout mice die from hydrocephalus and display ependymal cells with reduced density of cilia but without alterations in the length (26104135).

Model organism evidence

Mus musculus (1 reference)

This results indicate that the ventricular enlargement may be due to ciliopathy.

PMIDs: 26104135