SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000196220
UniProt:: O43295
OMIM:: 606525
Synonyms:: ARHGAP14, KIAA0411, MEGAP, SRGAP2, WRP

Cilia effects upon perturbation of SRGAP3

Cilia number / % ciliated:: Unknown
Loss-of-function effect:: Shorter cilia
Overexpression effect:: Unknown

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cytosol, nucleus

References: PMID:41005307, PMID:26104135

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Cell migration & adhesion
Signaling (Hedgehog, GPCRs, ion channels)

Function

Regulates the actin cytoskeleton, forming a signalling complex with WAVE-1 to regulate its activation. 10% of SrGAP3 knockout mice die from hydrocephalus and display ependymal cells with reduced density of cilia but without alterations in the length (26104135).

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