SRSF1

serine and arginine rich splicing factor 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000136450
UniProt:: Q07955
OMIM:: 600812
Synonyms:: SFRS1, ASF, SF2, SRp30a, SF2p33, MGC5228

Subcellular localization

nucleus, cytosol

Function

SR-family splicing factor that shuttles between the nucleus and cytoplasm. Mice with a nuclear-retained SRSF1 (Srsf1 NRS/NRS knock-in) show small body size, hydrocephalus and immotile sperm, with reduced translation and abundance of multiciliogenesis proteins and disrupted ciliary ultrastructure and motility. SRSF1 shuttling is required for motile ciliogenesis (PMID 34338635).

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