SSNA1

SS nuclear autoantigen 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000176101
UniProt:
O43805
OMIM:
610882
Synonyms:
N14, NA14

Cilia effects upon perturbation of SSNA1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
No effect
Overexpression effect:
Unknown

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

centrosome, cilia, cytosol, nucleus, basal body

References: PMID:41005307, PMID:21289087

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Required for ciliary transport and signalling. It may regulate postciliary endocytosis of constitutive GPCRs and facilitate endocytosis from the cell surface following transit through cilia, as knockdown inhibits Gli3 ciliary accumulation but retain normal length cilia (21289087).