SSNA1

Cilia effects upon perturbation of SSNA1

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

No effect

Overexpression effect:

Unknown

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

centrosome, cilia, cytosol, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Protein processing & maturation
• Signaling (Hedgehog, GPCRs, ion channels)

Function

Required for ciliary transport and sig lling. It may regulate postciliary endocytosis of constitutive GPCRs and facilitate endocytosis from the cell surface following transit through cilia, as knockdown inhibits Gli3 ciliary accumulation but retain normal length cilia (21289087).