SSX2IP

SSX family member 2 interacting protein

Ensembl:
ENSG00000117155
UniProt:
Q9Y2D8
OMIM:
608690
Synonyms:
HMSD1

Cilia effects upon perturbation of SSX2IP

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased grip strength

Subcellular localization

basal body, centrosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Centriolar satellite and microtubule anchoring protein. Interacts with PCM-1. Essential for the assembly of primary cilia and the recruitment of Cep290 to both satellites and the basal body, it also promotes the ciliary entry of the entire BBSome. Knockdown limits targeting of somatostatin receptor 3, and significantly reduces axoneme length. Possible novel cooperator of Rab8 (24356449). Binds the microtubule-nucleator gamma- tubulin complex. Knockdown of its orthologue in zebrafish, results in ciliary defects and disturbs left-right asymmetry. Microtubule anchoring role to the basal body is required for primary cilia formation (24397932).

Model organism evidence

Xenopus (1 reference)

SSX2IP, also known as Msd1 or ADIP, is a component of cell junctions, centriolar satellite protein and a targeting factor for ciliary membrane proteins.

PMIDs: 34710136

Danio rerio (1 reference)

Msd1/SSX2IP-dependent microtubule anchorage ensures spindle orientation and primary cilia formation.

PMIDs: 24397932

Mus musculus (1 reference)

The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.

PMIDs: 24356449