STAT1

Cilia effects upon perturbation of STAT1

Cilia number / % ciliated:

Incrased cilia number

Loss-of-function effect:

Longer cilia

Overexpression effect:

Decreased

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.07) PMID:41160700

Phenotypes

Mouse phenotype:

impaired righting response, decreased lymphocyte cell number, increased monocyte cell number, decreased mean corpuscular volume, increased basophil cell number, decreased mean corpuscular hemoglobin, increased neutrophil cell number, increased lymphocyte cell number, enlarged lymph nodes, abnormal gait, increased large unstained cell number, increased leukocyte cell number, increased eosinophil cell number, decreased circulating alkaline phosphatase level, decreased bone mineral content

Subcellular localization

cilia associated gene, cytosol, nucleus

Functional category

• Ciliary assembly/disassembly
• T cell biology
• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• Transcription regulation

Function

Proteogenomic profiling reveals that primary ciliogenesis drives sig l transducer and activator of transcription (STAT1) and death receptor 5 (DR5) sig ling in AT/RT cell line models ( 36127323).