STAT3

signal transducer and activator of transcription 3

Ensembl:
ENSG00000168610
UniProt:
P40763
OMIM:
102582
Synonyms:
APRF

Cilia effects upon perturbation of STAT3

Cilia number / % ciliated:
Incrased cilia number

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.20) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Polycystic Kidney Disease

Subcellular localization

cilia associated gene, cytosol, endosome, microtubules, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Viral interactions
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells( 25136113)