STAT4

signal transducer and activator of transcription 4

Ensembl:
ENSG00000138378
UniProt:
Q14765

Cilia effects upon perturbation of STAT4

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-12.24) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
cornea opacity
Mouse ciliopathy phenotype:
small kidney, abnormal vitreous body morphology, cataract, abnormal kidney morphology

Subcellular localization

basal body, flagella, nucleus

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Transcription regulation

Function

STAT4 has localized in basal body,flagella.